1. Despite indicates an illogical occurrence.
We had a good time despite the bad weather.
2. In spite of has the same meaning and usage as despite.
We had a good time in spite of the bad weather.
Road Safety Tips
Car Drivers Wear seat belts
Always wear seat belts and make sure children are seated in the backseat while you drive. If possible, instal your cars with airbags as to avoid any injuries incase of an accident.